FDA approves costly drug to fight Duchenne Muscular DystrophyBy Sheila Mcguire Feb 14, 2017
The company intends to charge $89,000 a year for a drug which has been available in Canada, the United Kingdom and Europe for decades for $1,000-$1,600 a year, according to the Wall Street Journal.
It commonly implies the medication will be secure by insurance, and the evidence that is utilized to support the approval may induce doctors to use the medications. "This also seems to be another example of gaming the Orphan Drug Act, which was meant to try and encourage research into new therapeutic entities for people who have rare diseases - and it doesn't seem like this is that". Image credit: USA Today.$89,000 a year to treat the disease in the U.S.
Marathon anticipates a smooth transition for patients ready getting deflazacort from overseas pharmacies. Before now, this drug-known as deflazacort-has been available to patients who suffer from a quite devastating and generally fatal disease, Duchenne muscular dystrophy. However, the drug was never approved by the FDA as no companies thought it profitable enough to jump through the regulatory hoops necessary to sell it in the U.S.
Orange alligator appears in SC neighborhood pond
As you can see, this gator isn't your typical reptile. "Representin' that Clemson National Championship", someone else exclaimed. An orange alligator in SC is being called the " Trumpagator " after being spotted at a pond in Hanahan, located near Charleston.
Russia, Turkey to work closer after deadly Syria airstrike
Rebel officials said the clash took place in a village south-west of the ISIS-held city of Al-Bab on Thursday. Peskov said that Russian Federation and Turkey will jointly investigate the deadly incident.
Trump may expand Iranian group to terror list
White House enthusiasm for the directives was high at the end of last week, with plans to release them as soon as Tuesday. There is also concern about United States military and embassy personnel in Iraq who could become a terror target.
Marathon Pharmaceutical's deflazacort, a steroid, aims to improve the lives of patients with Duchenne muscular dystrophy by improving muscle function, potentially allowing them to walk, feed themselves and control their wheelchairs longer. It is a practice that has prompted congressional investigations for other companies in the past, most notably, Turing Pharmaceuticals, the firm formerly run by one time hedge-fund manager Martin Shkreli, who took a drug used to treat AIDS patients, and increased 5,000 percent from $13.50 a pill to $750.
However, the price hike underscores a problem with American pharmaceutical companies exploiting the orphan drug label to reap massive profits from medicine. This is the 9th time that the FDA grants the pediatric disease priority voucher. Their ages ranged between 5 and 15 at the beginning of the trial. At week 12, patients taking deflazacort had improvements in a clinical assessment of muscle strength across a number of muscles compared to those taking a placebo. By week 52, patients in the Emflaza group maintained an overall stability in average muscle strength.
Though side effects caused by the drug have been reduced over the years, they remain similar to those resulting from other corticosteroids. More importantly, the drug results in less severe side effects typically experienced when using corticosteroids, scuh as bone mass loss, weight gain, behavioral issues, and glucose intolerance. It can also lead to a reduction in the density of the bones.
You may also like...
DeVos vote bodes ill for bipartisanship
Feb 14, 2017
DeVos's qualifications to serve as secretary of education are so weak that two Republican senators declined to vote for her. Conceptually, charter schools work to return equilibrium to the relationship between the individual and the state .
Game Update Brings in Hot Wheels to Soccer Arena
Feb 13, 2017
For those who don't pay for the Rocket League Hot Wheels DLC, it will also usher in some free updates for all players. Each Hot Wheels vehicle will come with six decals and an exclusive set of wheels.
Undocumented immigrant deported after ICE detainment in Arizona
Feb 13, 2017
Officials warned Mexicans in the U.S.to be cautious, aware of their rights and to stay in contact with their local consulate. Seven people were arrested Wednesday night as protesters blocked an ICE van that was believed to be transporting Garcia.
New York, Boston Braced for Foot of Snow: Schools Closed, Flights Canceled
Feb 12, 2017
Near whiteout conditions were possible, with snow expected to fall at a clip of 2 to 4 inches per hour at the storm's height. NY is expecting up to a foot of snow, while parts of New England could receive as much as 18 inches.
Major Cheese Recall Issued, Due To Possible Listeria Contamination
Feb 12, 2017
There have been no known illnesses reported to the company due to the products affected by the recall, the company says. Sargento Chef Blends Shredded Nacho & Taco Cheese, 8 oz., UPC 4610040041, with sell-by dates of H14JUN17 and H12JUL17.
Mark Warburton resigns as Rangers manager
Feb 12, 2017
They are still competing for that second spot which Rangers Football Club feel they should be getting, and the supporters certainly feel they should be getting that.
Justin Timberlake, John Legend to Sing at the Oscars
Feb 12, 2017
Although they were written by the film's composer Justin Hurwitz, Legend appears in the film as a central musical character. Singer-songwriter Legend shared with Common an Oscar for the original song "Glory " from "Selma" (2014).
Sensex declines by 62 points, Nifty trades below 8800
Feb 11, 2017
ICICI Bank, Axis Bank, HDFC Bank, SBI, Kotak Bank, Bank of Baroda, Yes Bank and Federal Bank all fell by up to 1.71 per cent. Lupin, Dr Reddy's Lab, BPCL and ITC were the other prominent losers in the index falling between 1.5-1.7 per cent.
Now We Know Why Negan Is A Sociopath On 'The Walking Dead'
Feb 10, 2017
Rick and the Alexandrians are gearing up for an all out war with evil Negan after they were repressed in the first eight episodes. Rick is confident as he will see his group and many others band together with the common goal of taking down Negan.
Former PM Mohamed Abdullahi Farmajo wins landmark presidential vote in Somalia
Feb 10, 2017
Farmajo was sworn in on Wednesday after outgoing President Hassan Sheikh Mohamud conceded defeat following two rounds of voting. The new MPs and Senators are expected to jointly vote in a secret ballot for the new Somali President tomorrow.